360589 Sigma-Aldrich


contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%

Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329755267

  •  NACRES NA.21



Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads,
Quality Level   200
grade   ACS reagent
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.0%
form   liquid
autoignition temp.   610 °F
contains   250 ppm BHT as inhibitor
expl. lim.   1.8-11.8 %
application(s)   HPLC: suitable
impurities   ≤0.015% peroxide (as H2O2)
  ≤0.05% water
evapn. residue   ≤0.03%
color   APHA: ≤20
refractive index   n20/D 1.407 (lit.)
pH   ~7
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
solubility   water: soluble
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2


General description

Tetrahydrofuran (THF) is a widely used organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. The effect of THF on the biological systems has been studied.


Tetrahydrofuran (THF) was used as a solvent in the following processes:
• RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization of p-acetoxystyrene.
• Synthesis of di-tert-butyl-phosphinoferrocene.
• Synthesis of n-TiO2-based amphiphilic polymer brushes.
• To dissolve the LiCl from the Mg2Si nanoparticles.
It may be used in the following studies:
• As an O-donor ligand to form coordination complexes.
• As mobile phase solvent in high-performance liquid chromatography.
• As a solvent in the preparation of spin-coated poly(bisphenol A decane ether).
• Synthesis of THF doped hydrogen clathrate hydrates.


1, 6×1, 2.5, 4, 4×4 L in glass bottle

18, 200 L in steel drum

500, 6×500 mL in glass bottle

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989

Safety & Documentation

Safety Information

Signal word 
Supplemental Hazard Statements 
EUH018 - EUH019
UN 2056 3 / PGII
WGK Germany 
Flash Point(F) 
-6.2 °F - closed cup
Flash Point(C) 
-21.2 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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