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30450 Sigma

Daunorubicin hydrochloride

≥90% (HPLC)

Synonym: Daunomycin hydrochloride

  • CAS Number 23541-50-6

  • Empirical Formula (Hill Notation) C27H29NO10 · HCl

  • Molecular Weight 563.98

  •  Beilstein Registry Number 4229221

  •  EC Number 245-723-4

  •  MDL number MFCD04974507

  •  PubChem Substance ID 57648441

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Properties

Related Categories A - K, Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z,
biological source   synthetic
InChI Key   GUGHGUXZJWAIAS-QQYBVWGSSA-N
assay   ≥90% (HPLC)
form   solid
color   red to deep red
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   neoplastics
storage temp.   2-8°C

Description

Biochem/physiol Actions

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.

Packaging

5 mg, 25 mg

Application

Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.

General description

Chemical structure: aminoglycoside

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
HB7878000
Protocols & Articles
Peer-Reviewed Papers
15

References

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