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44270 Sigma

trans,trans-Farnesyl pyrophosphate ammonium salt

≥95.0% (HPLC)

Synonym: (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt, Farnesyl diphosphate ammonium salt

  • Empirical Formula (Hill Notation) C15H28O7P2 · xNH3

  • Molecular Weight 382.33 (free acid basis)

  •  Beilstein Registry Number 2482197

  •  PubChem Substance ID 329756482

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Properties

Related Categories Cell Biology, Metabolic Pathways, Metabolomics, Terpenoid Metabolism, Terpenoids More...
InChI Key   CPYJTMLHKIWGDF-NDHHSALASA-N
assay   ≥95.0% (HPLC)
storage temp.   −20°C

Description

Biochem/physiol Actions

Farnesyl pyrophosphate is a key intermediate in the biosynthesis of more complex sesquiterpenoids, higher terpenoids, and steroids and different biological functions have been discovered for FPP and the corresponding alcohol farnesol. FPP plays an important role in the posttranslational processing of Ras proteins. Mutated forms of Ras are associated with human cancer and are therefore investigated in cancer research.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Farnesyl diphosphate ammonium salt may be used to study the posttranslational process known as farnesylation that is used to modify important proteins such as the Ras oncogene.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Analysis of Isoprenoid Pathway Metabolites by LC-MS | Biofiles, Vol. 8, No. 17

Isoprenoid pathway metabolites such isoprenoidphosphates and-pyrophosphates are central biological intermediates leading to sterols, dolichols, ubiquinones, prenylated natural products and proteins. ...
Rudolf Köhling, Roland Meier, Bernhard Schönenberger and Roland Wohlgemuth

Sigma-Aldrich®, Buchs, Switzerland
Biofiles, Vol. 8, No. 17
Keywords: Buffers, Chromatography, High performance liquid chromatography, Individual protein Immunoprecipitation, Mass spectrometry, Metabolites, Separation, Solvents

New Metabolomics Products

The availability of metabolites is an important element for progress in metabolomics. We have expanded our collection in an effort to provide you with the metabolites needed to advance your research.
Keywords: Metabolites, Metabolomics

Peer-Reviewed Papers
15

References

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