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A0487 Sigma

Argatroban monohydrate

≥98% (HPLC)

Synonym: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid, Argipidine, MQPA

  • CAS Number 141396-28-3

  • Empirical Formula (Hill Notation) C23H36N6O5S · H2O

  • Molecular Weight 526.65

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Properties

Related Categories AN-AZ, Anticoagulants, Approved Therapeutics/Drug Candidates, Baxter, Bioactive Small Molecule Alphabetical Index,
assay   ≥98% (HPLC)
storage condition   desiccated
color   white to off-white
solubility   DMSO: ≥20 mg/mL
originator   Baxter
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Argatroban is a potent, seletive, univalent direct inhibitor of thrombin. It directly inhibits thrombin by binding only to its active site (thus univalent) as compared to Bivalent DTIs (hirudin and analogs) which bind both to the active site and exosite 1.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TM6126610

Documents

Certificate of Analysis


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Protocols & Articles

Articles

Anticoagulants

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BioFiles v7 n5, 2012, 25–26
Keywords: Anticoagulants, Cardiovascular, Pharmaceutical

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Proteinase-Activated Receptors

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