• USA Home
  • A0487 - Argatroban monohydrate

A0487 Sigma

Argatroban monohydrate

≥98% (HPLC)

Synonym: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid, Argipidine, MQPA

  • CAS Number 141396-28-3

  • Empirical Formula (Hill Notation) C23H36N6O5S · H2O

  • Molecular Weight 526.65



Related Categories AN-AZ, Anticoagulants, Approved Therapeutics/Drug Candidates, Baxter, Bioactive Small Molecule Alphabetical Index,
assay   ≥98% (HPLC)
storage condition   desiccated
color   white to off-white
solubility   DMSO: ≥20 mg/mL
originator   Baxter
storage temp.   2-8°C



5, 25 mg in glass bottle

Biochem/physiol Actions

Argatroban is a potent, seletive, univalent direct inhibitor of thrombin. It directly inhibits thrombin by binding only to its active site (thus univalent) as compared to Bivalent DTIs (hirudin and analogs) which bind both to the active site and exosite 1.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Discover your Target

Milli-Q® Water Purification Solutions
Protocols & Articles



Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 25–26
Keywords: Anticoagulants, Cardiovascular, Pharmaceutical

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

Proteinase-Activated Receptors

The search for a functional thrombin receptor, using expression cloning methods, led to the discovery of a G protein-coupled receptor that mediates the actions of thrombin on platelets and endothelia...
Keywords: Atomic absorption spectroscopy, Cancer, Cloning, Gastrointestinal, Gene expression, Inflammation, Ligands, Physiological Processes, Rearrangements, Transduction

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?