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A0752 Sigma-Aldrich

Adenosine 5′-diphosphoribose sodium salt

≥93%

Synonym: ADP-Ribose

  • CAS Number 68414-18-6

  • Empirical Formula (Hill Notation) C15H23N5O14P2

  • Molecular Weight 559.32

  •  MDL number MFCD00136017

  •  PubChem Substance ID 24890449

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Properties

Related Categories Biochemicals and Reagents, Coenzyme A and Other Acyl Transfer Reagents, Cofactors, Enzymes, Inhibitors, and Substrates
Quality Level   200
assay   ≥93%
storage temp.   −20°C
SMILES string   [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
InChI   1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
InChI key   NWPVXDZLQTURKI-UHFFFAOYSA-N

Description

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:
• to give a range of nicotinamide adenine dinucleotide (NADH)
• oxidation rates for the respiratory complex (CI/CIII/CIV)
• CI/alternative(AOX) pathway
• to measure poly(ADP-ribose) glycohydrolaseactivity
• poly(ADP-ribose) (PAR) binding competition assay
• oxidase (AOX) pathway
• to measure poly(ADP-ribose) glycohydrolase activity
• poly(ADP-ribose) (PAR) binding competition assay

Packaging

25, 100, 500 mg in poly bottle

Biochem/physiol Actions

ADP-Ribose is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are an important components of DNA repair and apoptosis signaling.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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