• USA Home
  • A4978 - Alendronate sodium trihydrate

EMAIL THIS PAGE TO A FRIEND
A4978 Sigma

Alendronate sodium trihydrate

≥97% (NMR), powder

Synonym: 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217

  • CAS Number 121268-17-5

  • Empirical Formula (Hill Notation) C4H12NaNO7P2 · 3 H2O

  • Molecular Weight 325.12

  •  MDL number MFCD01748233

  •  PubChem Substance ID 24724391

Purchase

Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Metabolism, Cancer Research,
InChI Key   DCSBSVSZJRSITC-UHFFFAOYSA-M
assay   ≥97% (NMR)
form   powder
color   white
solubility   water, double-distilled: 10 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Packaging

100 mg in glass bottle

Application

Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
SZ6523500

Documents

Certificate of Analysis

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What quality control assays are typically done on Product A4978, Alendronate sodium trihydrate?
The assays typically done on Product No. A4978 are appearance, solubility, elemental analysis for carbon, hydrogen and nitrogen (CHN) and proton NMR (1H-NMR) spectroscopy. The results of these assays may be found on the certificate of analysis for each lot.
How should I dissolve Product A4978, Alendronate sodium trihydrate?
This product is soluble in water at a concentration of 10 mg/mL.
I see that Product A4978, Alendronate sodium trihydrate, is a trihydrate. How was the water content determined?
Our supplier typically determines the water content by a loss on drying. We have not tested the water content in our labs here at Sigma by that method; we typically confirm the suppliers value by CHN (elemental analysis for carbon, hydrogen and nitrogen, comparing the measured values to the theoretical values for the trihydrate).
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions

Discover your Target

Stabilizer Protein and RNA Stabilization Reagents
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?