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A9730 Sigma

Adefovir dipivoxil

Synonym: 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine

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Properties

Related Categories Antibiotics, Antiviral, Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides,
InChI Key   WOZSCQDILHKSGG-UHFFFAOYSA-N
form   solid
solubility   ethanol: 50 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   −20°C

Description

Application

Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment.

Biochem/physiol Actions

Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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