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B157 Sigma-Aldrich

BQ-788

≥95%, solid

Synonym: 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle, N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt

  • CAS Number 156161-89-6

  • Empirical Formula (Hill Notation) C34H50N5NaO7

  • Molecular Weight 663.78

  •  MDL number MFCD00797882

  •  PubChem Substance ID 329773192

  •  NACRES NA.32

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Properties

Related Categories Antagonists, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Endothelin - Receptor Antagonists,
Quality Level   200
assay   ≥95%
form   solid
color   white
solubility   acetonitrile: 0.3 mg/mL
  DMSO: 1.2 mg/mL
  ethanol: 1.2 mg/mL
  H2O: slightly soluble
storage temp.   −20°C
SMILES string   [Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N3[C@@H](C)CCC[C@H]3C)C([O-])=O
InChI   1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1
InChI key   QCVIFBRTTLMEOV-FUKQNADPSA-M
Gene Information   human ... EDNRB(1910)
mouse ... EDNRB(13618)
rat ... EDNRB(50672)

Description

Application

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs), uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs), and human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

Selective ETB endothelin receptor antagonist.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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