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B5311 Sigma

Biperiden hydrochloride

≥98% (HPLC), powder

Synonym: 1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

  • CAS Number 1235-82-1

  • Empirical Formula (Hill Notation) C21H30ClNO

  • Molecular Weight 347.92

  •  EC Number 214-976-2

  •  PubChem Substance ID 329773254

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Properties

Related Categories Abbott, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Approved Therapeutics/Drug Candidates, B,
InChI Key   RDNLAULGBSQZMP-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   DMSO: >20 mg/mL
  H2O: insoluble
originator   Abbott

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TN3706000

Documents

Certificate of Analysis


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Making Headway
Protocols & Articles

Articles

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled receptors (GPCRs). They are relatively abundant and mediate many of the diverse actions of acetylcholine in the ...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Gene expression, Hormones, Molecular biology, Neurotransmitters, Parkinson Disease, Polymorphisms, Transduction

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers
15

References

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