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B5437 Sigma

Bendamustine hydrochloride hydrate

≥98% (HPLC)

Synonym: 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride, Treanda

  • Empirical Formula (Hill Notation) C16H21Cl2N3O2·HCl · xH2O

  • Molecular Weight 394.72 (anhydrous basis)

  •  MDL number MFCD16879055

  •  PubChem Substance ID 329773260

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Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index,
InChI Key   TWBJYCLUHINEDN-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   H2O: >30 mg/mL
originator   Teva
storage temp.   room temp

Description

Biochem/physiol Actions

Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. Bendamustine activates DNA-damage stress response and apoptosis; inhibits mitotic checkpoints; and induces mitotic catastrophe.

Packaging

5, 25 mg in glass bottle

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
DE1590000

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers
15

References

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