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B8262 Sigma

Benztropine mesylate

≥99% (TLC), powder

Synonym: Benzatropine mesylate, Benzotropine mesylate, Benztropine methanesulfonate

  • CAS Number 132-17-2

  • Empirical Formula (Hill Notation) C21H25NO · CH3SO3H

  • Molecular Weight 403.53

  •  EC Number 205-048-8

  •  MDL number MFCD00074784

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Properties

InChI Key   CPFJLLXFNPCTDW-BWSPSPBFSA-N
assay   ≥99% (TLC)
form   powder
solubility   H2O: 50 mg/mL (Solutions may be stored for several weeks at 4°C.)
storage temp.   2-8°C
Gene Information   human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Biochem/physiol Actions

Muscarinic acetylcholine receptor antagonist; inhibits the dopamine transporter.

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
YM3150000
Protocols & Articles
Peer-Reviewed Papers
15

References

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