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B9938 Sigma-Aldrich

Calycosin

≥98% (HPLC)

Synonym: 3′,7-Dihydroxy-4′-methoxy-isoflavone, 3′-Hydroxyformononetin, Cyclosin

  • CAS Number 20575-57-9

  • Empirical Formula (Hill Notation) C16H12O5

  • Molecular Weight 284.26

  •  PubChem Substance ID 329773327

  •  NACRES NA.25

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Properties

Related Categories Cell Biology, Isoflavones, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM) More...
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to light yellow
solubility   methanol: 1 mg/mL, clear, colorless
storage temp.   2-8°C
SMILES string   COc1ccc(cc1O)C2=CC(=O)c3ccc(O)cc3O2
InChI   1S/C16H12O5/c1-20-14-5-2-9(6-13(14)19)15-8-12(18)11-4-3-10(17)7-16(11)21-15/h2-8,17,19H,1H3
InChI key   QAGGICSUEVNSGH-UHFFFAOYSA-N

Description

Application

Calycosin, a phytoestrogen isoflavone, may be used to promote and study its mechanisms of angiogenesis via interaction with the estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway. Calycosin may be used to study its function and role in neuroprotection via prevention of reperfusion injury. Calycosin may be used as a calcium channel blocker. Calycosin can be used to study its role in protection of HUVECs from advanced glycation end products-induced macrophage infiltration.

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Isoflavone and phytoestrogen isolated froma traditional Chinese medicinal herb. Calycosin induces angiogenesis in HUVEC and promotes proliferation of estrogen-receptor positive cells in vivo and in vitro. Also functions as a vasorelaxant on rat thoracic aorta.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Traditional Medicinals and Cancer

Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, and Chloe McClanahan, Product Manager
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical

Peer-Reviewed Papers
15

References

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