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C3809 Sigma

Ceftazidime hydrate

≥90.0%, contains ~10% sodium carbonate as stabilizer

Synonym: 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum

  • CAS Number 120618-65-7

  • Empirical Formula (Hill Notation) C22H22N6O7S2 · xH2O

  • Molecular Weight 546.58 (anhydrous basis)

  •  MDL number MFCD00153936

  •  PubChem Substance ID 24892644

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   NMVPEQXCMGEDNH-TZVUEUGBSA-N
assay   ≥90.0%
form   powder
contains   ~10% sodium carbonate as stabilizer
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Packaging

1, 5 g in glass bottle

Application

Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.

Biochem/physiol Actions

Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

General description

Broad spectrum antibiotic; third generation cephalosporin

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solution stability of the Product C3809, Ceftazidime hydrate?
Unfortunately, we do not testProduct C3809, Ceftazidime hydrate, for solution stability.However, Chedru-Legros V. et al., Cornea, 29(7),807-11(2010), report5% solutions of ceftazidime 0.9% sodium chloride can be stored at -20°C for 6 months. Also, Mehta, S. et al., Retina, 31(7),1316-22 (2011), reports single-use polypropylene syringes retain potency, sterility, and stabilityfor 24 weeks when stored at -20°C or -80°C.
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Protocols & Articles
Peer-Reviewed Papers
15

References

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