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C4282 Sigma-Aldrich

Coenzyme A hydrate

≥85% (UV, HPLC)

Synonym: CoA

  • CAS Number 85-61-0 (anhydrous)

  • Empirical Formula (Hill Notation) C21H36N7O16P3S · xH2O

  • Molecular Weight 767.53 (anhydrous basis)

  •  Beilstein/REAXYS Number 77809

  •  MDL number MFCD06795839

  •  PubChem Substance ID 24892684

  •  NACRES NA.21

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Description

Application

Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.

Packaging

10 mg in glass bottle

25, 100 mg in poly bottle

Biochem/physiol Actions

Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. CoA plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.

Caution

The free acid is less stable than the sodium or lithium salt; 5% decomposition may occur within 6 months when stored at −20 °C.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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