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C7081 Sigma-Aldrich

WY-14643

Synonym: 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid

  • CAS Number 50892-23-4

  • Empirical Formula (Hill Notation) C14H14ClN3O2S

  • Molecular Weight 323.80

  •  MDL number MFCD00191335

  •  PubChem Substance ID 24892928

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression,
Quality Level   100
SMILES string   CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2
InChI   1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChI key   SZRPDCCEHVWOJX-UHFFFAOYSA-N
Gene Information   human ... PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013)
rat ... Ppara(25747)

Description

General description

WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.

Application

WY-14643 has been used:
• as a positive control for transfection and luciferase assay
• to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
• to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

Packaging

10 mg in glass insert

50 mg in glass bottle

Biochem/physiol Actions

Selective PPARα agonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
AG2915000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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