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CS0010 Sigma-Aldrich

β-Secretase (BACE1) Activity Detection Kit (Fluorescent)

 kit sufficient for 250 reactions

Synonym: BACE1 Activity Detection Kit (Fluorescent)

  •  NACRES NA.84

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Properties

Related Categories Alzheimer′s Disease, Assays/Reagents for Alzheimer′s Disease Research, Cell Analysis, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   300
usage   1 kit sufficient for 250 reactions
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... BACE1(23621)

Description

Biochem/physiol Actions

BACE1 is a transmembrane protease responsible for the β site cleavage of the amyloid precursor protein (APP) to produce amyloid β peptide (Aβ). The accumulation of Aβ in the brain is a primary cause for the progression of Alzheimer′s. BACE1 is a target for inhibitor drug discovery.

Suitability

The kit provides all the reagents required for an efficient detection of BACE1 activity. It contains an enzyme to be used for screening for potential BACE1 inhibitors. The assay is based on the fluorescence resonance energy transfer (FRET) method in which the fluorescence signal enhancement is observed after substrate cleavage by BACE1.

Kit component only

Description

Product #

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Fluorescent Assay Buffer 50 mL    
Stop Solution 15 mL    
Substrate (MOCA-SEV-NL-DAEFR-DNP-RR) 500 μL    
Assay Standard 140 μL    
BACE1 (β−Secretase) 300 units 100 μL    
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions. Hallmark pathohistological findings of AD include widespread ...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 4–8
Keywords: Alzheimer Disease, Gene expression, Genetic, Genetics, Inflammation, Metabolism, Phosphorylations

Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
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