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D048 Sigma-Aldrich

MPP+ iodide

≥98% (HPLC), powder

Synonym: 1-Methyl-4-phenylpyridinium iodide

  • CAS Number 36913-39-0

  • Empirical Formula (Hill Notation) C12H12IN

  • Molecular Weight 297.13

  •  MDL number MFCD00055096

  •  PubChem Substance ID 24893235

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 10 mg/mL, clear
SMILES string   [I-].C[n+]1ccc(cc1)-c2ccccc2
InChI   1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key   RFDFRDXIIKROAI-UHFFFAOYSA-M

Description

General description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Application

MPP+ iodide has been used:
• to induce oxidative stress in zebrafish embryos
• for the inhibition of glutamate uptake in mitochondria of astrocytes
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Packaging

1 g in glass bottle

100 mg in glass bottle

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Caution

Photosensitive.

Preparation Note

Solutions should be freshly prepared.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Target organs 
Respiratory system
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
UU6580000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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