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D1262 Sigma-Aldrich

P1,P4-Di(adenosine-5′) tetraphosphate ammonium salt

≥95% (HPLC), powder

Synonym: A(5′)p4(5′)A, Diadenosine tetraphosphate ammonium salt

  • CAS Number 102783-36-8

  • Empirical Formula (Hill Notation) C20H28N10O19P4 · xNH3

  • Molecular Weight 836.39 (free acid basis)

  •  MDL number MFCD00058622

  •  eCl@ss 32160414

  •  PubChem Substance ID 24277711

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Properties

Related Categories Adenosines/P2 Nucleotide Receptors (Purinergics), Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   JTLRVYSRZSPJKJ-AHKIGRPSSA-N
assay   ≥95% (HPLC)
form   powder
color   white to off-white
solubility   H2O: 50 mg/mL
storage temp.   −20°C
Gene Information   human ... PLD1(5337), PLD2(5338), PLD3(23646), PLD4(122618), PLD5(200150)

Description

Application

P1,P4-Di(adenosine-5′) tetraphosphate ammonium salt has been used as a substrate for nudix hydrolyse. It has also been used as a ATP analog and nudix substrate for cleavage factor II Im25 subunit.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Diadenosine polyphosphate (Ap4A) functions as a second messenger in pancreatic cells. Diadenosine polyphosphate is majorly stored in neuronal cells, thrombocytes and chromaffin. It stimulates phospholipase D, fluctuates intracellular calcium levels, induces nitric oxide release, activates 5′-nucleotidase, and inhibits adenosine kinase activity in vitro. The membrane-bound ectoenzymes in endothelial cells in blood plasma and smooth muscle cell metabolize Ap4A.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
AU7411600

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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