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E0514 Sigma-Aldrich

E-64c

Calpain Inhibitor

Synonym: (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

  • CAS Number 76684-89-4

  • Empirical Formula (Hill Notation) C15H26N2O5

  • Molecular Weight 314.38

  •  MDL number MFCD00132882

  •  PubChem Substance ID 24894369

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Properties

Related Categories A to C, Apoptosis Enzymes, Application Index, Biochemicals and Reagents, Calpain,
storage temp.   −20°C
SMILES string   CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O
InChI   1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
InChI key   SCMSYZJDIQPSDI-SRVKXCTJSA-N
Gene Information   human ... CAPN1(823)

Description

Biochem/physiol Actions

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Linkage

Synthetic analog of E-64

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RR0404200

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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