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E101 Sigma-Aldrich

S-(−)-Eticlopride hydrochloride

≥98% (HPLC), powder

Synonym: FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride

  • CAS Number 97612-24-3

  • Empirical Formula (Hill Notation) C17H25ClN2O3 · HCl

  • Molecular Weight 377.31

  •  MDL number MFCD00055132

  •  PubChem Substance ID 24278428

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Properties

Related Categories Antagonists - Dopaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
InChI Key   HFJFXXDHVWLIKX-YDALLXLXSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]27/D −7.2°, c = 0.3 in methanol(lit.)
color   off-white
solubility   H2O: soluble >10 mg/mL
  ethanol: soluble 2.6 mg/mL
  0.1 M HCl: soluble 7 mg/mL
Gene Information   human ... DRD2(1813)

Description

Application

S-(−)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Packaging

25, 100 mg in glass bottle

Biochem/physiol Actions

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2 receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Preparation Note

Solutions may be stored at 4° C for several days

Legal Information

Manufactured and sold with the permission of Astra AB.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CV2450000

Documents

Certificate of Analysis (COA)

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Making Headway

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Peer-Reviewed Papers
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References

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