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E3656 Sigma

(−)-Epothilone A

from Sorangium cellulosum, >95% (HPLC), solid

Synonym: EpoA

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
biological source   Sorangium cellulosum
InChI Key   HESCAJZNRMSMJG-KKQRBIROSA-N
assay   >95% (HPLC)
form   solid
storage condition   desiccated
  protect from light
storage temp.   −20°C

Description

Biochem/physiol Actions

(-)-Epothilone A is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoA exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 20 nM for MDR CCRF-CEM/VBL100 cells). Epothilone A is a competitve inhibitor of 3H-paclitaxel binding with comparable IC50 to paclitaxel in displacement competition assays. EpoA causes cell cycle arrest at the G2/M transition leading to cytotoxicity.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


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E2656 (−)-Epothilone B, from Sorangium cellulosum, ≥98% (HPLC)

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