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F8929 Sigma

Fluconazole

≥98% (HPLC), powder

Synonym: 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol

  • CAS Number 86386-73-4

  • Empirical Formula (Hill Notation) C13H12F2N6O

  • Molecular Weight 306.27

  •  MDL number MFCD00274549

  •  PubChem Substance ID 24724485

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Approved Therapeutics/Drug Candidates,
InChI Key   RFHAOTPXVQNOHP-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
solubility   DMSO: 5 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
originator   Pfizer
storage temp.   room temp
Gene Information   human ... CYP1A2(1544)

Description

Packaging

100 mg in glass bottle

Biochem/physiol Actions

Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
XZ4810000

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

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Peer-Reviewed Papers
15

References

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