• USA Home
  • G1146 - L-Glutamine–Penicillin–Streptomycin solution

G1146 Sigma-Aldrich

L-Glutamine–Penicillin–Streptomycin solution

with 200 mM L-glutamine, 10,000 U penicillin and 10 mg steptomycin/mL in 0.9% NaCl, sterile-filtered, BioReagent, suitable for cell culture



Related Categories A - K, Antibacterial, Antibiotic Solutions, Antibiotics, Antibiotics A to Z,
Quality Level   200
biological source   synthetic
sterility   sterile-filtered
product line   BioReagent
form   liquid
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
Mode of action   cell wall synthesis | interferes
  protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
shipped in   dry ice
storage temp.   −20°C



Used to reduce or eliminate bacterial contamination in cell, especially primary cell, cultures. Recommended for use in cell culture applications at 10 ml/L.

Biochem/physiol Actions

Mode of Action: Glutamine is essential as an energy source for most mammalian cells in culture because of its amino acid carbon skeleton. Penicillin acts by inhibiting bacterial cell wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome and causes miscoding.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.


Formulated with 200 mM L-glutamine, 10,000 units/ml penicillin, and 10 mg/ml streptomycin in 0.9% sodium chloride.

Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Related Content

Antibiotics Selection Guide

The Antibiotic Selection Guide enables researchers to spend more time on their research discoveries and less time seeking established antibiotic information. Link to hundreds of antibiotics for conta...
Keywords: Antibiotics, Cell biology, Cell culture, Genetic, High performance liquid chromatography, Reversed-phase chromatography

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

L-Glutamine in Cell Culture

Importance and uses of glutamine in serum-free eukaryotic, including hybridoma and mammalian, cell cultures.
Keywords: Alternative energy, Cell culture, Culture media, Deaminations, Metabolism, Oxidations, Transaminations, Vitamins

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?