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  • G1545 - Anti-Glutamate Receptor 3, Metabotropic antibody produced in rabbit

G1545 Sigma-Aldrich

Anti-Glutamate Receptor 3, Metabotropic antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-mGluR3



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunocytochemistry: 38 μg/mL using human brain, neurons and glia
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 38 μg/mL using human brain, neurons and glia
  western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   Q14832
Gene Information   human ... GRM3(2913)
mouse ... Grm3(108069)
rat ... Grm3(24416)



synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 3, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.


Anti-Glutamate Receptor 3, Metabotropic antibody produced in rabbit is suitable for:
• western blot analysis of mouse somatosensory cortex to examine the connexin 36 (Cx36) protein expression and electrotonic coupling incidence.
• western blot analysis of rat hypothalamus to study the Cx36 expression.
• immunocytochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 38μg/mL using human brain, neurons and glia.

Physical form

Solution in phosphate buffered saline, containing 0.1% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. Group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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