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G1626 Sigma-Aldrich

L-Glutamic acid monosodium salt hydrate

≥99% (HPLC), powder

Synonym: (S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

  • CAS Number 142-47-2 (anhydrous)

  • Empirical Formula (Hill Notation) C5H8NNaO4 · xH2O

  • Molecular Weight 169.11 (anhydrous basis)

  •  MDL number MFCD00013074

  •  PubChem Substance ID 24895069

  •  NACRES NA.32

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Properties

Related Categories Amino Acid, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, Metabolic Pathways,
Quality Level   200
assay   ≥99% (HPLC)
form   powder
color   white to off-white
InChI   1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;
InChI key   JYDGDQPVBSBYRT-UHFFFAOYSA-N
Gene Information   human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

Description

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Application

L-Glutamic acid monosodium salt hydrate has been used-
• as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine
• as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice
• as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce’s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants
• as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae
• as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage

Packaging

1 kg in poly bottle

100, 500 g in poly bottle

Biochem/physiol Actions

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington’s disease and Parkinson’s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

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Peer-Reviewed Papers
15

References

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