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G7048 Sigma

Proguanil hydrochloride

≥95% (HPLC)

Synonym: Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide

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Properties

Related Categories Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   SARMGXPVOFNNNG-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   solid
storage condition   desiccated
solubility   acetonitrile: water: ~1 mg/mL (60/40)
originator   AstraZeneca
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Application

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
DU1750000

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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