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GE17-5269-02

MabSelect Xtra

Cytiva, 17-5269-02, pack of 200 mL

  •  NACRES NA.56

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Properties

Related Categories Antibodies, Antibody Purification and Characterization, MabSelect mAb Purification, Protein A, G and L Resins, Supplementary Products More...
shelf life   Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
packaging   pack of 200 mL
mfr. no.   Cytiva, 17-5269-02
matrix   highly cross-linked agarose
avg. part. size   75 (d₅₀v is the median particle size of the cumulative volume distribution)
cleaning in place   2 - 12 (pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
working range   3 - 10 (pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
capacity   ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)(Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.)
suitability   suitable for bioprocess medium
storage temp.   2-8°C

Description

General description

MabSelect Xtra, with extra high dynamic binding capacity, is a member of the MabSelect family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.

Application

MabSelect Xtra has the same recombinant Protein A ligand as MabSelect but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

Features and Benefits

• Higher dynamic binding capacity than currently available Protein A chromatography media.
• Improved process economics through reduced raw materials costs and/or reduced number of cycles
• High purity capture due to high ligand selectivity and matrix hydrophilicity
• Slightly lower pressure/fLow properties compared to MabSelect SuRe and MabSelect

Analysis Note

www.gelifesciences.com.

Legal Information

MabSelect is a trademark of Cytiva

SuRe is a trademark of Cytiva

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Column Packing and Preparation for Affinity Chromatography of Antibodies

Appendix 5, Extracted from Affinity Chromatography Vol. 1: Antibodies, GE Healthcare, 2016  
Keywords: Affinity chromatography, Antimicrobials, Chromatography, Detergents, Gene expression, Separation, Solvents

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