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I127 Sigma-Aldrich

ICI 118,551 hydrochloride

≥98% (HPLC), powder

Synonym: (2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride

  • CAS Number 72795-01-8

  • Empirical Formula (Hill Notation) C17H27NO2 · HCl

  • Molecular Weight 313.86

  •  MDL number MFCD00153812

  •  PubChem Substance ID 24277782

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Description

Application

ICI 118,551 hydrochloride has been used:
• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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