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I8898 Sigma

Ivermectin

Synonym: 22,23-Dihydroavermectin B1, MK-933

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
InChI Key   AZSNMRSAGSSBNP-XPNPUAGNSA-N
form   powder
solubility   MEK: 50 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   parasites
originator   Merck & Co., Inc., Kenilworth, NJ
storage temp.   2-8°C
Gene Information   human ... ABCB1(5243), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)

Description

Other Notes

Primarily ivermectin B1a.

Packaging

1 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the molecular weight of Product No. I8898, Ivermectin?
This product is a mixture of two submoieties B1A, MW 891.1 and B1B, MW 877.1. It is typically predominantly B1A, so you may use a molecular weight of 890 in your calculations.
What is the solution stability of Ivermectin (Product No. I8898)?
Stock solutions of Ivermectin in DMSO at a concentration of 10 mM have been found to be stable for 2 weeks at -20°C, according to Shan, Q., et al., in Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel.J. Biol. Chem., 276(16), 12556-12564 (2001).
What is the composition of the submoieties B1A and B1B in Product No. I8898, Ivermectin?
Unfortunately we do not test each lot to determine the composition.In the past, lots have been ~95% B1A and ~5% B1B; however there will be lot-to-lot variation.
My question is not addressed here, how can I contact Technical Service for assistance?
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Peer-Reviewed Papers
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References

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