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K4013 Sigma

Kasugamycin hydrochloride from Streptomyces kasugaensis

≥90% (HPLC)

Synonym: 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

  • CAS Number 19408-46-9

  • Empirical Formula (Hill Notation) C14H25N3O9 · HCl

  • Molecular Weight 415.82

  •  MDL number MFCD00058459

  •  PubChem Substance ID 24896238

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Properties

Related Categories A - K, Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z,
biological source   Streptomyces kasugaensis
InChI Key   ZDRBJJNXJOSCLR-NZXABURVSA-N
assay   ≥90% (HPLC)
color   white to off-white
solubility   H2O: soluble 50 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Packaging

10 g in glass bottle

Application

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance.

Biochem/physiol Actions

Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.

General description

Chemical structure: aminoglycoside

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
NM7521800
Protocols & Articles
Peer-Reviewed Papers
15

References

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