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L5025 Sigma

Leflunomide

Immunosuppressant

Synonym: 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide

  • CAS Number 75706-12-6

  • Empirical Formula (Hill Notation) C12H9F3N2O2

  • Molecular Weight 270.21

  •  MDL number MFCD00867593

  •  PubChem Substance ID 24278516

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Description

Biochem/physiol Actions

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

Packaging

25, 100 mg in poly bottle

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
NY2354200

Expore Enzymes, Proteins & Cofactors
Protocols & Articles
Peer-Reviewed Papers
15

References

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