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M0267 Sigma-Aldrich

(±)-Methadone hydrochloride

powder, ≥98%

Synonym: 6-Dimethylamino-4,4-diphenylheptan-3-one hydrochloride

  • CAS Number 1095-90-5

  • Empirical Formula (Hill Notation) C21H27NO · HCl

  • Molecular Weight 345.91

  •  EC Number 214-140-7

  •  MDL number MFCD00058014

  •  PubChem Substance ID 24896546

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Channel Modulators,
Quality Level   200
assay   ≥98%
form   powder
drug control   USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
color   white to off-white
solubility   H2O: 50 mg/mL, clear, colorless to yellow
originator   Novartis
SMILES string   Cl.CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2
InChI   1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H
InChI key   FJQXCDYVZAHXNS-UHFFFAOYSA-N
Gene Information   human ... OPRM1(4988)

Description

Biochem/physiol Actions

μ opioid receptor agonist that desensitizes both the μ opioid receptor and the δ opioid receptor on chronic exposure; narcotic analgesic, characterized by a gradual onset of action and prolonged, milder withdrawal; may also block L-type calcium channels independently of its effects on opioid receptors.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Central nervous system
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
MJ6300000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

GC Analysis of Basic Drugs on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on Equity®-5
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Methadone Enantiomers and Methadone Metabolite EDDP on Astec® CYCLOBOND® I 2000 HP-RSP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methadone Enantiomers and Methadone Metabolite EDDP on Astec® CYCLOBOND® I 2000 HP-RSP
Keywords: Analgesics, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methadone Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methadone Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Analgesics, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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