M3536 Sigma-Aldrich

Mycophenolic acid

powder, BioReagent, suitable for cell culture

Synonym: 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, NSC 129185

  • CAS Number 24280-93-1

  • Empirical Formula (Hill Notation) C17H20O6

  • Molecular Weight 320.34

  •  Beilstein/REAXYS Number 1295848

  •  EC Number 246-119-3

  •  MDL number MFCD00036814

  •  PubChem Substance ID 24896854

  •  NACRES NA.76



Related Categories Antibiotics, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Cell Biology,
Quality Level   300
biological source   Penicillium brevicompactum
product line   BioReagent
form   powder
application(s)   cell culture | mammalian: suitable
color   white to yellow-white
mp   <143.0 °C
solubility   methanol: 50 mg/mL
Mode of action   enzyme | inhibits
storage temp.   2-8°C
SMILES string   COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI   1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
Gene Information   human ... IMPDH1(3614), IMPDH2(3615)



50, 250 mg in serum bottle


Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

Biochem/physiol Actions

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.


As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Preparation Note

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Immune system
UN 3077 9 / PGIII
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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