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M5255 Sigma

Mycophenolic acid

≥98%

Synonym: 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, NSC 129185

  • CAS Number 24280-93-1

  • Empirical Formula (Hill Notation) C17H20O6

  • Molecular Weight 320.34

  •  Beilstein Registry Number 1295848

  •  EC Number 246-119-3

  •  MDL number MFCD00036814

  •  PubChem Substance ID 24896987

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
Quality Level   PREMIUM
biological source   Penicillium brevicompactum
InChI Key   HPNSFSBZBAHARI-RUDMXATFSA-N
assay   ≥98%
color   white to yellow-white
mp   <143.0 °C
solubility   methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
Mode of action   enzyme | inhibits
originator   Novartis
storage temp.   2-8°C
Gene Information   human ... IMPDH1(3614), IMPDH2(3615)

Description

Application

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

Biochem/physiol Actions

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.

Caution

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Packaging

50, 250 mg in serum bottle

Preparation Note

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Immune system
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
MP8050000

Documents

Certificate of Analysis

Certificate of Origin


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Peer-Reviewed Papers
15

References

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