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M7065 Sigma-Aldrich

MK-912 hydrochloride hydrate

≥98% (HPLC)

Synonym: (2S-trans)-1,3,4,5′,6,6′,7,12b-Octahydro-1′,3′-dimethyl-spiro[2H-benzofuro[2,3-a]quinolizine-2,4′(1’H)-pyrimidin]-2′(3’H)-one hydrochloride hydrate, L-657,743

  • CAS Number 111466-41-2 (free base)

  • Empirical Formula (Hill Notation) C20H25N3O2 · xHCl · yH2O

  • Molecular Weight 339.43 (anhydrous free base basis)

  •  PubChem Substance ID 24278567

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Properties

Related Categories Adrenergics, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   WVVGVFGUHPXSJZ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: soluble 16 mg/mL
originator   Merck & Co., Inc., Kenilworth, NJ
Gene Information   human ... ADRB2(154)

Description

Biochem/physiol Actions

Selective α2-adrenoceptor antagonist

Other Notes

Material is hygroscopic.

Packaging

5, 25 mg in glass bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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