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P0098 Sigma-Aldrich

Pediocin from Pediococcus acidilactici

≥95% (HPLC), buffered aqueous solution



Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action,
assay   ≥95% (HPLC)
form   buffered aqueous solution
concentration   0.1 mg/mL in 0.1 M sodium acetate pH 5.0
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
shipped in   dry ice
storage temp.   −20°C


Biochem/physiol Actions

Pediocins are class IIa bacteriocins that are produced by Pediococcus acidilactici. They are cationic peptides with molecular masses of about 2,700 to 4,000 Da, that show strong activity against pathogenic bacteria such as Listeria monocytogenes, Clostridicum perfringes, Enterococcus faecalis, and Staphylococcus aureus.4 This antimicrobial action of pediocins is based on interactions with the cytoplasmic membrane, resulting in pore formation and cell death. These interactions also cause a change in membrane potentials, which leads to a loss of the proton motive force and an efflux of intracellular ions, ultimately causing cell death. They have been shown to inhibit Listeria monocytogenes.


Pediocins have molecular masses of about 2,700 to 4,000 Da. They are potential food biopreservatives used to control food-borne pathogens and spoilage.

General description

Chemical structure: peptide

Other Notes


Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Antimicrobial Peptides

With bacterial resistance and emerging infectious diseases becoming potential threats to humans, ribosomally synthesized antimicrobial peptides have become a promising focus area in antibiotic resear...
Chloe McClanahan
BioFiles 2009, 4.3, 4.
Keywords: Antibiotics, Antimicrobials, Antiparasitics, Antivirals, Apoptosis, Cancer, Clinical, Diseases, Environmental, Fermentation, Food Safety, Gene expression, Genetic, Genetics, Infectious Diseases, Microbiology, Peptide synthesis, Pesticides, Respiratory

Peer-Reviewed Papers


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