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P3892 Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt >70,000

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Properties

Related Categories Amino Acids, Biochemicals and Reagents, Homopolymers, Polyamino Acids
Quality Level   200
form   powder or solid
mol wt   >70,000
application(s)   bioconjugation: suitable
color   white to off-white
storage temp.   −20°C
SMILES string   Cl.NC(CCCNC(N)=N)C(O)=O
InChI   1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1
InChI key   PQEISBBDIRAKGR-LFELFHSZSA-N

Description

Application

Poly-L-arginine hydrochloride has been used:
• as polyelectrolyte solution in the synthesis of biodegradable capsules
• as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells
• in assay for the determination of binding activity of C-reactive protein for polycationic ligands

Packaging

10, 50, 100 mg in poly bottle

Biochem/physiol Actions

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

Quality

Contains 3% or less ornithine residue by TLC.

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Carmen Scholz Department of Chemistry, University of Alabama in Huntsville Huntsville, AL 35899 Email: scholzc@uah.edu
Keywords: Addition reactions, Asymmetric synthesis, Building blocks, Catalysis, Degradations, Living polymerization, PEGylations, Polymerization reactions, Precipitation, Proteomics, Ring-opening polymerization, Solvents

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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