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P4668 Sigma-Aldrich

Praziquantel

anthelminic, neurogenic

Synonym: 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

  • CAS Number 55268-74-1

  • Empirical Formula (Hill Notation) C19H24N2O2

  • Molecular Weight 312.41

  •  Beilstein/REAXYS Number 761557

  •  EC Number 259-559-6

  •  MDL number MFCD00058531

  •  PubChem Substance ID 24278635

  •  NACRES NA.85

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action, Antiparasitic / Antiprotozoal / Anthelminthic,
Quality Level   200
form   powder or crystals
Mode of action   cell membrane | interferes
antibiotic activity spectrum   parasites
storage temp.   −20°C
SMILES string   O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
InChI   1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
InChI key   FSVJFNAIGNNGKK-UHFFFAOYSA-N

Description

Application

Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca2+ channels and is a potential small molecule neurogenic.

Biochem/physiol Actions

Praziquantel increases the permeability of the tegmentum to Ca2+ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release. Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms). Recent studies have indicated that praziquantel binds to a varient of the β-subunit of the voltage gated Ca2+ channel and to actin, which is a component of some Ca2+ channels.

Other Notes

1g,5g,25g

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
UQ4150000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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