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P6004 Sigma-Aldrich

Prednisolone

≥99%

Synonym: 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrohydrocortisone, 1-Dehydrocortisol, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

  • CAS Number 50-24-8

  • Empirical Formula (Hill Notation) C21H28O5

  • Molecular Weight 360.44

  •  Beilstein/REAXYS Number 1354103

  •  EC Number 200-021-7

  •  MDL number MFCD00003649

  •  PubChem Substance ID 24898725

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   OIGNJSKKLXVSLS-VWUMJDOOSA-N
Quality Level   200
assay   ≥99%
form   powder
mp   240 °C (dec.) (lit.)
originator   Johnson & Johnson
Gene Information   human ... AR(367), ESR1(2099), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Nr3c1(14815)
rat ... Ar(24208)

Description

General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Application

Prednisolone has been used for the Δ1-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Packaging

1, 5, 10, 25 g in poly bottle

100 mg in poly bottle

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TU4152000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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