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PZ0010 Sigma

Pregabalin

≥97% (NMR)

Synonym: (S)-3-(Aminomethyl)-5-methylhexanoic acid, CI-1008, PD-144723

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Properties

Related Categories Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Channel Modulators,
InChI Key   AYXYPKUFHZROOJ-ZETCQYMHSA-N
assay   ≥97% (NMR)
form   white powder
drug control   USDEA Schedule V
solubility   deionized water: ≥10 mg/mL
originator   Pfizer
storage temp.   room temp

Description

Biochem/physiol Actions

Pregabalin is a lipophilic GABA analog/ligand at α2δ subunit of voltage-dependent Ca2+ channels. Pregabalin is an anticonvulsant, anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.

Other Notes

This compound was developed by Pfizer for Ion Channel research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

Calcium Channels

The voltage-gated calcium channels constitute one group of a superfamily of ion channels that also includes sodium and potassium channels and amongst which exists functional, sequence and topological...
Keywords: Cardiovascular, Clinical, Diabetes, Gene expression, Hormones, Ligands, Neurotransmitters

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Pfizer Compounds for Ion Channels

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Ion Channels

UHPLC/MS Analysis of Anticonvulsants on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Anticonvulsants on Ascentis® Express HILIC
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

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