R5143 Sigma-Aldrich

Rutin hydrate

≥94% (HPLC), powder

Synonym: Quercetin-3-rutinoside hydrate, Vitamin P hydrate

  • CAS Number 207671-50-9

  • Empirical Formula (Hill Notation) C27H30O16 · xH2O

  • Molecular Weight 610.52 (anhydrous basis)

  •  Beilstein/REAXYS Number 75455

  •  EC Number 205-814-1

  •  MDL number MFCD01319140

  •  PubChem Substance ID 24899379

  •  NACRES NA.25



Related Categories Acacia, Allium cepa (Onion), Allium sativum (Garlic), Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants,
Quality Level   200
assay   ≥94% (HPLC)
form   powder
color   yellow to green
mp   195 °C (dec.) (lit.)
solubility   pyridine: 50 mg/mL
  DMSO: soluble
  aqueous base: soluble
SMILES string   [H]O[H].O[C@H]1[C@H](OC[C@H]([C@H]2O)O[C@@H](OC(C3=O)=C(C4=CC=C(O)C(O)=C4)OC5=C3C(O)=CC(O)=C5)[C@H](O)[C@H]2O)O[C@H]([C@@H]([C@H]1O)O)C
InChI   1S/C27H30O16.H2O/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9;/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3;1H2/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-;/m0./s1


General description

Rutin hydrate has radioprotective and antiplatelet activity. Rutin reduces hepatic and blood cholesterol levels.


Rutin hydrate has been used:
• as an inhibitory compound against Skeletonema costatum
• to analyze the phenolic component and antioxidant activity of nettle
• to assess the flavonoid content in Propolis

Biochem/physiol Actions

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B1 and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 354 nm)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 354 nm)
Keywords: Chromatography, High performance liquid chromatography

Simplified Determination of Rutin in Anti-Aging Skin Cream Formulations

Rutin, also known as rutoside, quercetin-3-O-rutinoside, or sophorin, is a quercetin glycoside found in various plants, including buckwheat and asparagus. The chemical structure contain units of Ruto...
Keywords: Filtration, High performance liquid chromatography, Sample preparations

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Peer-Reviewed Papers


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