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S4441 Sigma

DL-Sulforaphane

≥90% (HPLC), synthetic, liquid

Synonym: 1-Isothiocyanato-4-(methylsulfinyl)-butane

  • CAS Number 4478-93-7

  • Empirical Formula (Hill Notation) C6H11NOS2

  • Molecular Weight 177.29

  •  MDL number MFCD00198068

  •  PubChem Substance ID 24724610

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Properties

Related Categories Antioxidant, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Functional Foods,
biological source   synthetic
InChI Key   SUVMJBTUFCVSAD-UHFFFAOYSA-N
assay   ≥90% (HPLC)
form   liquid
solubility   DMSO: soluble 40 mg/mL
  H2O: insoluble
compatibility   for use with ABI 7500
shipped in   dry ice
storage temp.   −20°C

Description

Application

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Biochem/physiol Actions

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S4441.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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