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S5895 Sigma-Aldrich

Sangivamycin hydrate from Streptomyces rimosus

Synonym: 7-Deaza-7-carbamoyladenosine hydrate

  • CAS Number 18417-89-5

  • Empirical Formula (Hill Notation) C12H15N5O5 · xH2O

  • Molecular Weight 309.28 (anhydrous basis)

  •  MDL number MFCD00214391

  •  PubChem Substance ID 24899678

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Properties

Related Categories AIDS and Viral Research Reagents, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecule Alphabetical Index,
InChI Key   QTYUIEDCERYPNJ-CCUUNMJDSA-N
solubility   0.5 M HCl: complete 5 mg/ml
  glacial acetic acid: complete 50 mg/ml
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
  viruses
storage temp.   2-8°C

Description

General description

Chemical structure: nucleoside

Application

Sangivamycin hydrate from Streptomyces rimosus may be used in PKC-mediated cell signaling studies.

Packaging

1, 10 mg in glass bottle

Biochem/physiol Actions

A cytotoxic purine nucleoside, active against human cytomegalovirus (HCMV); inhibits protein kinase C.

Sangivamycin is a deazapurine nucleoside analog produced by Streptomyces rimosus that arrests cell cycle at the G2 phase. It inhibits the activity of protein kinase C (PKC) and rhodopsin kinase and at higher concentrations it also inhibits protein kinase A and b-adrenergic receptor kinase. The phosphorylation of histone H1 protein is also one mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers.4,5,6

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
UY9355000

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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