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S8751 Sigma

Sulfaguanidine

Synonym: 4-Amino-N-(aminoiminomethyl)benzenesulfonamide, 4-Amino-N-guanylbenzenesulfonamide

  • CAS Number 57-67-0

  • Empirical Formula (Hill Notation) C7H10N4O2S

  • Molecular Weight 214.24

  •  Beilstein Registry Number 2695326

  •  EC Number 200-345-9

  •  MDL number MFCD00038136

  •  PubChem Substance ID 24899810

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents,
biological source   synthetic (Organic)
InChI Key   BRBKOPJOKNSWSG-UHFFFAOYSA-N
form   powder
color   white to off-white
solubility   1 M HCl: soluble 50 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
Gene Information   human ... F2(2147), PRSS1(5644)

Description

Application

Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.

Packaging

25, 100, 500 g in poly bottle

Biochem/physiol Actions

Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

General description

Chemical structure: sulfonamide

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WO8575000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
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