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SML0023 Sigma-Aldrich

5-Iodo-A-85380 dihydrochloride hydrate

≥98% (HPLC)

Synonym: 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   DCVONLXGZUKNSI-CZDIJEQGSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   H2O: ≥22 mg/mL
storage temp.   −20°C

Description

Application

5-Iodo-A-85380 dihydrochloride hydrate may be used in nicotinic acetylcholine receptor-mediated signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

5-Iodo-A-85380 increases the influx of extracellular Ca+2 in rat cortical neurons and exhibits protective effects against glutamate-induced neurotoxicity. Studies reveal that it also activates α6β2 nicotinic acetylcholine receptors.

5-Iodo-A-85380 is a highly selective α4β2 nicotinic receptor agonist. The Ki values for binding to the human and rat receptors are 12 and 10 pM, respectively.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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References

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