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SML0041 Sigma-Aldrich

Batimastat

≥98% (HPLC)

Synonym: BB-94; (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

  • CAS Number 130370-60-4

  • Empirical Formula (Hill Notation) C23H31N3O4S2

  • Molecular Weight 477.64

  •  MDL number MFCD00866533

  •  PubChem Substance ID 329825111

  •  NACRES NA.77

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥15 mg/mL
shipped in   wet ice
storage temp.   −20°C
SMILES string   CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc2cccs2)C(=O)NO
InChI   1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChI key   XFILPEOLDIKJHX-QYZOEREBSA-N

Description

Application

Batimastat has been used to inhibit matrix metalloproteinases (MMPs) activity in various studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Batimastat is hydroxamate-type inhibitor of matrix metalloproteinases (MMP). It inhibits the growth and spread of lung tumors, breast cancer regrowth and human colon tumor growth and spread in mouse models. Batimastat reduces MMP-mediated vascular dysfunction and vessel wall damage and enhances the sealing ability and bond strength of dental adhesives.

Batimastat is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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