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SML0066 Sigma-Aldrich

NGB 2904 hydrochloride

≥98% (HPLC)

Synonym: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

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Description

Application

NGB 2904 hydrochloride may be used in cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.

NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Dopamine Receptors

Dopamine receptors were initially differentiated into two major types based on the ability of dopamine to stimulate (D1) or inhibit (D2) adenylyl cyclase activity and produce the second-messenger mol...
Keywords: Atomic absorption spectroscopy, Dopamine agents, Gene expression, Genetic, Genetics, Ligands, Methylations, Parkinson Disease, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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