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SML0196 Sigma

Resiquimod

≥98% (HPLC)

Synonym: 4-Amino-2-(ethoxymethyl)-alpha, R-848, R848, S28463, alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, R
InChI Key   BXNMTOQRYBFHNZ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
  protect from light
color   white to tan
solubility   DMSO: 10 mg/mL, clear (warmed to 60 °C)
shipped in   wet ice
storage temp.   −20°C

Description

Packaging

10, 50 mg in glass bottle

Application

Resiquimod may be used in immunological and cancer-related cell signaling studies.

Biochem/physiol Actions

Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities.

Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.

Features and Benefits

This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NJ5911320

Documents

Certificate of Analysis


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Protocols & Articles

Articles

Cytokine Receptors (Interleukin-1 Receptor/TIR Family)

The interleukin-1/TIR family in animals comprises three subgroups of proteins; of these, two are type I integral membrane receptor proteins and the third is a group of intracellular proteins. All fam...
Keywords: Gene expression, Hormones, Inflammation, Ligands, Transduction

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

Peer-Reviewed Papers
15

References

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