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SML0366 Sigma

Cipamfylline

≥98% (HPLC)

Synonym: 8-Amino-1,3-bis(cyclopropylmethyl)-3,9-dihydro-1H-Purine-2,6-dione, BRL 61063

  • CAS Number 132210-43-6

  • Empirical Formula (Hill Notation) C13H17N5O2

  • Molecular Weight 275.31

  •  PubChem Substance ID 329825367

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   KSPYMJJKQMWWNB-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Cipamfylline is a PDE4 inhibitor that has been shown to cause a cellular redistribution of PDE4A4 into accretion foci, through an association with the ubiquitin scaffolding protein p62.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. They function with adenylyl and guanylyl cyclases to regulate the amplitude and duration of responses triggere...
Keywords: Amplification, Atomic absorption spectroscopy, Catalysis, Diabetes, Gene expression, Genetic, Hormones, Inflammation, Neurotransmitters, Obesity, Parkinson Disease, Phosphorylations, Physiological Processes, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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