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SML0427 Sigma-Aldrich

Cardionogen-2

≥98% (HPLC)

Synonym: 6-(3,4-Dimethoxyphenyl)-3-(2-pyridinyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole, 6-(3,4-Dimethoxyphenyl)-3-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole, CDNG2, vuc198

  • CAS Number 578755-52-9

  • Empirical Formula (Hill Notation) C16H13N5O2S

  • Molecular Weight 339.37

  •  MDL number MFCD04025197

  •  PubChem Substance ID 329825422

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   MEWRLQUBVOVSGN-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution; warmed)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Cardionogen-2 is a biphasic modulator of cardiogenesis that enlarges the size of the zebrafish embryonic heart by promoting cardiomyocyte formation. Also, cardionogen-2 promotes murine ES cells to differentiate into beating cardiomyocytes. Apparently, cardionogen-2 inhibits Wnt/b-catenin dependent transcriptional activity. Treatment of zebrafish embryos with cardionogen-2 significantly enlarged both the atrium and ventricle, without causing apparent defects of embryonic morphology or other organ development.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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